Direct antioxidant properties of thiamin

For the elite that go through more than half a kg bag of thiamin in a year, consider this [1]Lukienko, P. I., et al. “Antioxidant properties of thiamine.” Bulletin of experimental biology and medicine 130.3 (2000): 874-876.:

“[..]thiamine directly interacts with free radicals and hydroperoxides, undergoes oxidation, and produces antioxidant effects related to the transfer of (2H+ + 2e−—) from the NH2 group of the pyrimidine ring to radicals.”

MDA: Multidimensional Data Analysis

Yet, it doesn’t seem viable to sustain it [2]Smithline, Howard A., Michael Donnino, and David J. Greenblatt. “Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects.” BMC clinical pharmacology 12.1 (2012): 1-10.:

10−6 M = 1000 nmol/L

There are the unusual responders of thiamin that deviate from the norm, but the levels reached remain below those tested previously. It remains possible for it to provide relief if it’s rapidly reacted where oxidants are building up.

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